Wednesday, May 31, 2006

Today in Science



Centrosomes may have their own RNA-based genome. ScienceNOW

An arctic Norwegian island will house a repository of the world’s seeds, just in case. Reuters




Prehistoric ecosystem found in a cave in Israel. Reuters

Mount St. Helen’s is acting up. AP




Canadian researchers are teaming up to find an early test for ovarian cancer. CBC


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UN report says the spread of AIDS may be slowing. NYT, BBC, CBC, NYT, LAT

But the drive to stop AIDS is still coming up short. Reuters

UNAIDS meets today to try and boost anti-HIV efforts. WP

India has passed South Africa for most AIDS cases. AP

SE Asia needs to step up anti-HIV efforts. Reuters




Production of oil in Canada is having a negative impact on the environment. WP




Diabetes incidence has significantly increased in the US. Reuters

Canadians are apparently healthier than Americans. AP, LiveScience.com

Ginko biloba may actually help the brain. ScienceNOW

4 out of 5 Europeans support a public smoking ban. BBC




Bush administration is cutting energy conservation programs. CSM

2 new studies link global warming with stronger hurricanes. NYT




Another study says that a reduction in pollution is making storms stronger. LiveScience.com




DC insiders are starting an internet campaign to get a 2008 bipartisan presidential ticket. WP

More on imprisoned Egyptian bloggers. WP




Rome is hosting a large bird flu meeting. AP




3 armed boy to have surgery. BBC


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Tuesday, May 30, 2006

Today in Science



Some aid is getting to Indonesian earthquake victims. Reuters, AP, AP, Der Spiegel

The US is testing an early warning system for earthquakes. AP




The Yangtze river in China is being killed by pollution. Reuters




DNA to catch burglars in the OC? LAT


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Head of the UN’s AIDS program says we are losing the fight against HIV/AIDS. AP




A bad diet is as bad for you as smoking. Reuters

New mechanical pump for the heart developed that does not require open heart surgery to insert. BBC, Guardian

They make you sick, then sell the cure. WP




NASA looks to artificial intelligence to guide future interplanetary probes. NYT

The rovers on Mars are already being upgraded to make some decisions. BBC



Some (not many) companies are trying to reduce their greenhouse gas emissions without governmental regulation. NYT

Poison ivy grows faster and is itchier when CO2 levels are higher. CBC, WP, LiveScience.com, Nature, AP




Use of e-voting machines is still contentious. WP

Ad subsidized cell phone calls on the way. NYT, Reuters




Egyptian blogger continues writing from his prison cell. AP




New Orleans levee system failed because it was too simplistic in design. NYT




Chinese baby has 3 arms. AP


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Monday, May 29, 2006

Today in Science



Indonesian earthquake death toll tops 5000. WP, Reuters, AP

Lack of genetic diversity in bananas may lead to their extinction. Guardian




Record-sized hammerhead shark caught off Florida coast. CBC, AP




Scientists show how tumors sabotage the immune system. BBC

New data shows that the drug Herceptin increases progression free survival in breast cancer patients. Reuters

Scientists learn 1 reason why exercise fights cancer. Reuters


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Over 2 million kids worldwide have AIDS. AP, Reuters




Maker of Tamiflu put on bird flu alert after recent outbreak in Indonesia. AP


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Friday, May 26, 2006

This Week in Science



Mice in lab have inherited a trait without inheriting the corresponding gene. AP, CBC, BBC, ScienceNOW, Nature

Mice deaths caused by RNA interference experiments. NYT, Nature

See also my take on these stories. More RNAi

Biologists convene to adopt code of conduct for creation of new life. Guardian




Helpful explanation of an NIH panel’s findings on multi-vitamin use. WP

Study: Marijuana smoking does not increase lung cancer risk. Reuters, ScienceNOW, WP




Voyager II is near the edge of our solar system. CNN




Scientists say current estimates of global warming are too low. Guardian

Australian, European, and Californian scientists: Global warming is speeding up. Reuters, BBC, Reuters

Warming may increase the size of subtropical deserts. Reuters, CSM, LiveScience.com, AP

Reviews of Al Gore’s climate change movie. NYT, Nature, CSM




Cloak of invisibility? CBC, Reuters, LiveScience.com, Nature, NG, AP




The Senate is pressured on stem cell bill. WP


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HIV originated in chimpanzees. Nature, AP, NYT, BBC, CBC, WP, Reuters, LiveScience.com, NG




This is going to be another active hurricane season. LiveScience.com, CNN

New Orleans is the most likely place to be hit this hurricane season. Reuters




The death of an Indonesian family may have been caused by the first human to human to human transmission of bird flu. NYT, BBC, AP

2 siblings die of bird flu in Indonesia. AP




Wild bear seen in Germany for first time in 170 years. NG, Der Spiegel, AP




Science scores are up in elementary schools but not for older kids. AP, NYT




Scientists piece together how whales lost their hind legs. CSM


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Today in Science

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HIV originated in chimpanzees. Nature, AP, NYT, BBC, CBC, WP, Reuters, LiveScience.com, NG

UN group reports on AIDS treatment progress in hardest hit countries. AP




Warming may increase the size of subtropical deserts. Reuters, CSM, LiveScience.com, AP

Kyoto states will meet to discuss greenhouse emissions cut for post-2012. (Sans the US, of course.) Reuters

Another review of Al Gore’s global warming movie. CSM




Cloak of invisibility? CBC, Reuters, LiveScience.com, Nature, NG, AP

Yahoo! and eBay join forces. WP, FT, NYT, LAT, Reuters, BBC, AP

Researchers develop nanomaterial that pulls water out of the air. ScienceNOW




Migrating birds from Europe and Africa are in decline. BBC, Reuters




Thalidomide gets FDA approval for use against bone-marrow cancer. AP




Sorry ladies: A drink a day is only good for men. BBC, Reuters

FDA approves new shingles vaccine. AP




House Judiciary committee approves internet gambling ban. Reuters, AP

Beat that dead horse: Full House votes to open drilling in Alaska refuge, chances of passing the Senate are slim. NYT, WP, AP




2 siblings die of bird flu in Indonesia. AP


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Thursday, May 25, 2006

More RNAi

Some of you may remember that a couple of months ago I wrote about some advances in RNA interference (RNAi) technology. Well, today brought 2 new stories about RNAi and, since they also dealt with mice (with which I am also somewhat familiar) I thought I would elaborate on them.

RNAi has been demonstrated to be a possible epigenetic mechanism. This essentially means that small interfering RNAs (siRNA) can cause a mouse to inherit a mutant trait from its parent (white tipped extremities) without inheriting the actual DNA that encodes the corresponding mutant gene (Kit). Apparently, the Kit mutant gene produces a lot of what are probably siRNA precursors and these siRNAs are contained in the sperm and/or egg that becomes the new mouse – thereby silencing the wild-type gene copies found in the developing pup.

The articles that I read both made big deals of the fact that this mechanism operates outside of classic Mendelian genetics but there are other such mechanisms that have been known for years and this is just one more. (Not that epigenetics is not an important field, but the writers acted like we could toss Mendel in the toilet.)

The more interesting question to me is: would these siRNAs and the associated gene silencing be heritable? Could the next generation also have white tipped extremities? I am unfamiliar with any research that suggests siRNAs can self-replicate, so I doubt it. They would inevitably degrade and, without being replaced by the mutant gene, lose their gene-silencing effect. It is possible the effect could last a generation or 2 but probably not much longer. But the only way to find out is to breed them.

Another interesting point is that, normally, when a mouse has 2 mutant copies of the Kit gene, they die but when they have 1 wild-type copy, they live (but display the characteristic white tipped extremities). Since the mice in this experiment lived (and display white tips), it implies that the siRNA mediated gene silencing in this case is incomplete (otherwise the mice would be dead).
AP, CBC, BBC, ScienceNOW, Nature


The second story today is about research into the potential toxicity of RNAi. In this study, researchers introduced 49 different types of short-hairpin RNA (shRNA) into the livers of mice and monitored for toxicity. 36 were “severely toxic” and 23 caused death within 2 months. It seems the shRNAs overwhelmed the cellular mechanisms that deal with shRNA, siRNA, and miRNA; which is necessary for normal cellular function.

That sounds pretty bad, right? We had better just chuck this whole technology into the toilet with Mendel, right?

No.

While this is an important, cautionary study it does not mean that RNAi will not be an incredibly effective therapeutic tool. A few things to keep in mind here:

1. The researchers used shRNA which appears to be more toxic than siRNA. siRNA has not shown any problems in the very few human RNAi tests that have and are being conducted.

2. High doses of shRNA were used and the toxicity was worse with greater dose. Like most drugs (or anything for that matter), the more you have in your system the more likely you will experience adverse effects.

3. 13/49 shRNAs tested were not toxic. This may seem like “The-glass-is-slightly-over-one-quarter-full” optimism but this result occurred without any attempt to design the molecules to avoid toxicity. That’s not bad. You do not get nearly that high a percentage of small molecules tested as pharmaceuticals that have no toxicity.

The bottom line is that this study has shown that caution is needed in RNAi testing. Overall, that is a good thing and will, hopefully, help avoid any setbacks to RNAi therapy caused by toxicity. That really hurt traditional gene therapy and, with some diligence, hopefully RNAi can avoid that pitfall.
NYT, Nature


All in all, an important set of discoveries regarding RNAi. Keep your eye on this technology, it will be coming sooner than you think.


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Today in Science



Mice in lab have inherited a trait without inheriting the corresponding gene. AP, CBC, BBC, ScienceNOW, Nature

Mice deaths caused by RNA interference experiments. NYT, Nature

Scientists are trying to produce cell networks on chips to reduce animal testing. Guardian




Lobsters can detect, avoid other diseased lobsters. CBC, Reuters, LiveScience.com




Risk is low for colon cancer for 10 years after negative colonoscopy. WP


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Scientists learn more about proteins on the surface of the HIV virus. Reuters




Japanese diet is healthier than US. AP




President Bush wants new nuclear plants to deal with climate change. NYT, WP




Honda has developed technology that allows brain waves to control a robot. AP

Canon is going to stop making film cameras. Reuters




Science scores are up in elementary schools but not for older kids. AP, NYT




Scientists piece together how whales lost their hind legs. CSM




Democrats see stem cells as good election year issue. AP

House reconsiders anti-online gambling bill, this time without Abramhoff influence. WP

Former head of FDA took “Plan B” decision out of the hands of senior staff. Reuters




Swans may be the first to bring bird flu into the US. AP




New Orleans is the most likely place to be hit this hurricane season. Reuters




2 cloned mules are set to race. AP, LiveScience.com


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Wednesday, May 24, 2006

Today in Science



The death of an Indonesian man may have been caused by the first human to human to human transmission of bird flu. NYT, BBC, AP




New type of cement may cut smog levels. FT




Wild bear seen in Germany for first time in 170 years. NG, Der Spiegel, AP


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Expert says fight against AIDS is gaining momentum. Reuters

Is there a genetic trait that could help fight AIDS? CBC

Increasing IV drug use is increasing the spread of HIV in India. BBC




Study: Marijuana smoking does not increase lung cancer risk. Reuters, ScienceNOW

Poor kids are more likely to be fat. Reuters

Study: Linoleic acid can change the distribution of body fat. Reuters

The US may draw nurses from poor countries, leaving them dangerously understaffed. NYT

Possible gene transfer therapy seen for impotence. Reuters




New telescopes may be able to detect life on distant planets by observing the light reflected of off them. BBC, NG

Voyager II is near the edge of our solar system. CNN




Reviews of Al Gore’s climate change movie. NYT, Nature

NASA is monitoring ice caps in Canada. CBC

Australian, European, and Californian scientists: Global warming is speeding up. Reuters, BBC, Reuters

Plan for nuclear fusion reactor gets go ahead. Guardian




Nike iPod shoes? AP, Reuters, FT, LAT, BBC

Microsoft releases beta versions of new products. Seattle Times, NYT, Reuters, PC World, AP




Humans may prevent new species from evolving. NYT




The Senate is pressured on stem cell bill. WP


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Tuesday, May 23, 2006

Today in Science



Biologists convene to adopt code of conduct for creation of new life. Guardian




Another cancer vaccine on the way? Guardian


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Drug trial in Cambodia ended by protests. WP




Helpful explanation of an NIH panel's findings on multi-vitamin use. WP

Kenya and Brazil call on wealthier nations to spend more on researching diseases that affect poor countries. Al Jazeera

University of Iowa researchers have developed a faster mumps test. AP

New "“seeing machine"” could restore some sight to people with severely limited vision. NYT

New asthma treatment tested. AP

Americans do not get preventive healthcare. Reuters

Possibly mutated virus is spreading like wildfire in the Indian Ocean. Nature




Scientists say current estimates of global warming are too low. Guardian

Bush v. Gore round 2: This time its about climate change. AP




Radio Free Internet? NYT




Virologist: Bird flu unlikely to reach US any time soon. Reuters

New vaccine for bird flu shows promise. (In birds.) ScienceNOW




This is going to be another active hurricane season. LiveScience.com, CNN

If a hurricane were to hit New York, the US economy could be devastated. NG




Documents may show that AT&T aided the government domestic surveillance program. WP


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Saturday, May 20, 2006

This Week in Science



Children in the East African drought region need immediate assistance. Reuters

3 major hurricanes are predicted to hit the US this season. Reuters




Merck waits for approval of cervical cancer vaccine. WP

FDA panel backs cervical cancer vaccine. AP, LAT

New genetic engineering technique may have huge potential to cure cancer. BBC




Merck may have discovered new class of antibiotics. WP, CBC, ScienceNOW, BBC, LiveScience.com




Human ancestors may have interbred with chimpanzees. CBC, WP, NYT, WP, Reuters, LiveScience.com, Nature, NG, BBC




Nebraska fossil bed named national landmark. NG




Astronomers say they have found a solar system similar to ours. NYT, Reuters, USAT, ScienceNOW, NG

The Washington Post ran a series of articles commemorating the Challenger disaster. WP




Neanderthal DNA sequenced. Nature

Human chromosome 1 sequencing completed. Reuters, Nature




Disease spawned by climate change may kill millions in Africa. Reuters, BBC

African mountains will no longer have snow capped peaks. LiveScience.com

GM to introduce more fuel efficient engines in 2007 models. Reuters, AP




Nancy Reagan is pushing the Senate on change in stem cell law. (Seriously, how many times do I have to put this thing up?) WP




WHO confirms 5 new bird flu deaths in Indonesia. WP, BBC, Reuters

WHO says no human to human transmission of bird flu found in Indonesian deaths. NYT, WP, AP




DNA tests may reveal Christopher Columbus’ origins. WP

Bellsouth says it did not give the NSA any phone records. WP

Verizon also denies giving phone records to NSA. WP, WP

Federal judge will not release documents that may show AT&T gave phone records to the NSA. WP

BellSouth wants a retraction from USA Today over NSA phone record story. WP,AP


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Friday, May 19, 2006

Today in Science



Some animals can think ahead. (Best of these headlines: "“Planning of the Apes".) Reuters, LiveScience.com, ScienceNOW, NG

Possibly not extinct woodpecker still has not been found. NYT, Reuters, AP




Deep-sea fishing stocks are being depleted. Reuters, BBC




Experiment sees light go "backwards"” and possibly exceed the standard speed of light. LiveScience.com




FDA panel backs cervical cancer vaccine. AP, LAT

New genetic engineering technique may have huge potential to cure cancer. BBC


/

Federal judge eliminates Bush administration prostitution pledge as a condition for receiving AIDS prevention funds. AP




Patient dies of Creutzfeldt-Jakob disease (human form of mad cow), others may have been infected. AP

More people may be susceptible to infection with Creutzfeldt-Jakob disease than previously thought. Guardian




GM to introduce more fuel efficient engines in 2007 models. Reuters, AP

Exxon under fire for failing to address climate change. Reuters

Al Gore has a climate change movie. Reuters



Dell to end exclusive chip deal with Intel amid drop in profits. FT, AP, NYT, AP, LAT




Scientist says Indonesian "hobbit" is not a unique species, but an individual with dwarfism. CBC, WP, NYT, NG, AP, Guardian




Guess who is not ready for bird flu today? Answer: The states. AP

WHO says no human to human transmission of bird flu found in Indonesian deaths. NYT, WP, AP




BellSouth wants a retraction from USA Today over NSA phone record story. WP, AP


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Thursday, May 18, 2006

Today in Science



Merck may have discovered new class of antibiotics. WP, CBC, ScienceNOW, BBC, LiveScience.com

Multi-vitamins may not be as good for you as you think. WP, Reuters, WP, LAT, LiveScience.com

FDA: RU-486 risk unclear. WP, WP

FDA approves new Parkinson's drug. WP

CDC advisory board wants more Mumps vaccinations. WP




Human ancestors may have interbred with chimpanzees. CBC, WP, NYT, WP, Reuters, LiveScience.com, Nature, NG, BBC

Scientists may have found "missing link" between non-flowering and flowering plants. CSM




Retired US aircraft carrier sunk in Gulf of Mexico to make man made coral reef. WP, Reuters




Human chromosome 1 sequencing completed. Reuters, Nature




Astronomers say they have found a solar system similar to ours. NYT, Reuters, USAT, ScienceNOW, NG




Scientists want Congress to fund research into "“plug-in hybrids"”. WP




North Carolina, Tennessee will try new method of "No Child Left Behind"” student evaluation. WP, NYT




Federal judge will not release documents that may show AT&T gave phone records to the NSA. WP


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Wednesday, May 17, 2006

Today in Science



Study says prolonged sitting, not air pressure and oxygen levels to blame for developing blood clots on airplanes. BBC, CBC, Reuters, ScienceNOW, Nature

Study shows Cuban sugar cane based cholesterol treatment is ineffective. WP




The Exxon Valdez oil spill is still damaging Alaskan wildlife. CBC, Reuters, ScienceNOW




Merck waits for approval of cervical cancer vaccine. WP

Synthetic marijuana drug for chemotherapy patients approved. CNN




Dying comet to pass by earth. Al Jazeera

Spaceports on the way? CNN




Anti-spamming campaign defeated by spam. WP

Discovery to start selling shows on iTunes. WP

Rival company sues to ban iPod sales. FT, SF Chronicle, Reuters

Apple releases new laptops with Intel chips. BBC




Proposed Omaha, Nebraska school redistricting law challenged under equal protection clause. NYT

Legitimacy of Newsweek high school rankings questioned. NYT

University of Colorado professor who compared 9/11 victims to Nazis accused of academic misconduct. NYT




Senators want to eliminate late fees in Medicare drug plan. NYT




WHO confirms 5 new bird flu deaths in Indonesia. WP, BBC, Reuters




Bubonic plague found in animals in Utah. CNN

Verizon also denies giving phone records to NSA. WP, WP


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Tuesday, May 16, 2006

Today in Science



Neanderthal DNA sequenced. Nature


/

AIDS nearing crisis point in Russia. WP




There is no evidence of an "Iraq War Syndrome"” similar to the "Gulf War Syndrome"”. CBC, BBC, Reuters

New federal guidelines want most women treated as pre-pregnant all the time. WP




Coral to be decimated by climate change. BBC

African mountains will no longer have snow capped peaks. LiveScience.com




Yahoo! is changing its home page today. BBC, WP

MLB wants fantasy baseball leagues to pay for use of players' names and stats. NYT

MTV to launch iTunes-esque online music store. FT, WP

Supreme Court rules in favor of eBay in patent dispute case. SF Chronicle, WP, Reuters, Seattle Times, ScienceNOW




Nancy Reagan is pushing the Senate on change in stem cell law. (Seriously, how many times do I have to put this thing up?) WP




3 major hurricanes are predicted to hit the US this season. Reuters




Bellsouth says it did not give the NSA any phone records. WP

Separated conjoined twins are getting better. WP


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Monday, May 15, 2006

Today in Science



Children in the East African drought region need immediate assistance. Reuters




Disease spawned by climate change may kill millions in Africa. Reuters, BBC

Less of the Arctic ocean froze this year than ever before. Guardian

Poor nations will urge wealthy nations to do more to combat climate change. Reuters




China's Three Gorges Dam will provide hydroelectric power but the damage to the environment could be severe. Al Jazeera

Invasive Zebra mussels eradicated for first time. WP

Dead penguins covered with oil found in Argentina. NG




Scientists discover protein that regenerates the optic nerve. Guardian

Drug company draws fire for anti-diarrhea drug produced by genetically modified rice. LAT

Conjoined twins separated. WP, WP

DNA tests may reveal Christopher Columbus' origins. WP

British Prime Minister Blair voices support for laboratory testing of animals. Reuters

AstraZeneca wants to buy a biotech company. NYT, BBC

Chinese scientist faked new microchip. NYT, FT, BBC, Reuters




Nebraska fossil bed named national landmark. NG


/

A vaccine against Chancroid shows promise in pigs, could help reduce the spread of HIV. Reuters




The Washington Post is running a series of articles commemorating the Challenger disaster. WP




South Korean scientists unveil polymer that conducts electricity. LiveScience.com




No state will meet 'No Child Left Behind'’ teacher quality goals. WP

Anti-drug prevention programs in schools may do more harm than good. LAT




Republicans may try to reduce penalties for people who enroll late in the Medicare drug plan. WP, NYT, LAT




Bird flu seems to have been largely eliminated in southeast Asia. NYT

The WHO looks to tackle bird flu. Der Spiegel


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Saturday, May 13, 2006

This Week in Science

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Newsweek ran a series of articles about 25 years of the AIDS epidemic. Newsweek

CDC wants HIV testing to be a standard part of physicals. CNN




The NSA knows who you have been calling. WP, WP Unless you use Qwest. WP




Scientific journal publishers are not happy about bill which would require free access to journal articles about US funded research. NYT




X-Prize for super fuel efficient car to be announced. CSM

"H-prize"” for hydrogen car trying to be established by Congress. LiveScience.com




Climate changes (not humans) killed off mammoths. CBC, Reuters, LiveScience.com, ScienceNOW, WP, USAT, NG

Dolphins recognize each other'’s names. Reuters, BBC, LiveScience.com, ScienceNOW, Nature, NG

Half-grizzly, half-polar bear shot in Canada. USAT

New genus of monkey discovered in Tanzania. BBC, CNN, LiveScience.com, CBC, Reuters, Guardian




Researchers find that lesbian's brains response to sex hormones is similar to men. CNN, WP, LiveScience.com, NG




US has high newborn death rate for an industrialized country. WP But still not as bad as Africa. BBC, Reuters




Senate to consider bill that would allow insurance companies to ignore state mandated coverage requirements. WP

Democrats may filibuster Republican health insurance bill. WP

Senate health insurance bill may be close to defeat. WP, WP




UK embryos may be screened for disease genes. WP, Guardian, ScienceNOW, Nature


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Friday, May 12, 2006

Today in Science



The NSA knows who you have been calling. WP, WP Unless you use Qwest. WP

Yahoo! wants the US government to help it stop helping China jail dissidents. (You heard me.) Reuters

Microsoft may have tried to buy Yahoo! FT




New genus of monkey discovered in Tanzania. BBC, CNN, LiveScience.com, CBC, Reuters, Guardian




New pill approved to help quit smoking. WP

Scientists differ on RU-486. WP, Reuters, SF Chronicle

Flu vaccine rationing debated. WP, BBC, WP, NG




Should crime suspect'’s family members be DNA tested? LiveScience.com, NYT, WP




Climate change may be happening faster than estimated, humans responsible. Reuters

190 countries to meet to combat climate change. Reuters

Reduced CO2 emissions from biofuels quantified in England. Reuters




South Korean stem cell scientist charged with fraud and embezzlement. BBC, NYT, Reuters


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Thursday, May 11, 2006

Today in Science



Climate changes (not humans) killed off mammoths. CBC, Reuters, LiveScience.com, ScienceNOW, WP, USAT, NG

Congress is trying to establish "H-prize" for a hydrogen car. LiveScience.com




UK embryos may be screened for disease genes. WP, Guardian, ScienceNOW, Nature, BBC

Exercise may reduce risk of skin cancer. LiveScience.com


/

Scientists have learned more about how HIV takes over cells. BBC




Half-grizzly, half-polar bear shot in Canada. USAT




Most eligible Americans are enrolled in the Medicare drug plan. Reuters

Scientists will meet to discuss abortion drug RU-486. NYT, Reuters




Google to refocus on search engine. FT, WP

No .xxx domain names for porn sites. WP, BBC

States step up oversight of e-voting machines. WP




New version of the SAT is resulting in lower scores. WP, NYT




Senate health insurance bill may be close to defeat. WP, WP




UC San Francisco receives $16 million for stem cell center. WP

Pet cloning. Guardian




Bird flu vaccine trial elicits positive response in volunteers. Reuters

Migrating birds have not spread bird flu from Europe to Africa and back as feared. NYT


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